Endocrine Abstracts

Objective: NPY2R is a G-protein-coupled receptor which is highly expressed in orexigenic NPY/AGRP neurons within the arcuate nucleus, a major integrator of appetite control in the hypothalamus. Genetic evidence coming from animal and association studies, has identified NPY2R as a candidate gene for obesity. Therefore we have designed an extensive mutation and CNV-analysis investigating the prevalence of genetic and structural variation in NPY2R.Design an...

Background: Growth hormone deficiency (GHD) in children comes in different etiologies and can be either isolated or combined with other pituitary hormone deficiencies. The diversity in GHD types and the variable duration of GH therapy complicate assessments of long-term treatment outcome. We characterized GHD patients at the end of GH therapy in Belgium and Luxemburg and evaluated height and adiposity outcomes in relation to GHD type.Methods: Anthropomet...